Personalised medicine in solid tumours
Our group focuses on different areas of research.
Erectile dysfunction: Endothelial dysfunction is one of the first symptoms of erectile dysfunction (ED) and is closely related to atherosclerosis and risk factors such as diabetes mellitus (DM), both characterised by an advanced inflammatory and oxidative state. Vardenafil is one of the most effective 5-phosphodiesterase inhibitors in patients with ED and DM. We have determined the plasma proteome of DM patients and the effect of vardenafil administration on the expression of proteins related to inflammatory oxidative stress and cellular homeostasis. We have observed a significant negative correlation between plasma levels of beta-tropomyosin and the IIEF-EFI index. Elevated plasma beta-tropomyosin levels indicate cell damage and loss of cell regenerative capacity.
Urothelial cancer: Exosomes are extracellular vesicles that act as potent intercellular mediators containing membrane proteins and cytosolic, specific mRNAs and miRNAs, and that can be obtained from fluids such as urine. We have analysed the content of miRNA and urinary exosome proteins in order to find diagnostic markers for urothelial bladder cancer. Some of these miRNAs are involved in tumour cell proliferation, inhibition of tumour suppressor genes, activation of EMT and metastatic status, are significantly reduced in the urinary exosomes of patients with urothelial bladder carcinomas and may be useful as non-invasive diagnostic biomarkers in bladder cancer.
Regarding diagnostic techniques, we have optimised the endourological, therapeutic and diagnostic approach for urothelial cancer of the upper tract.
Carlos Manuel Olivier Gómez
Hospital Universitario La Princesa
| Other team members. Hospital Universitario La Princesa:
Zamorano-León JJ, Olivier C, de Las Heras N, Mateos-Cáceres PJ, Brime Menéndez R, Rodríguez-Sierra P, Martín Palacios N, Manso LS, Modrego J, Segura A, Macaya C, López-Farré AJ. Vardenafil Improves Penile Erection in Type 2 Diabetes Mellitus Patients with Erectile Dysfunction: Role of Tropomyosin. J. Sex. Med. 2013. 10: 3110-3120. FI: 3.150(Q1). PMID: 24112450. DOI: 10.1111/jsm.12324.
Resel Folkersma, Luis, San Jose Manso, Luis, Galante Romo, Isabel, Moreno Sierra, Jesus, Olivier Goemez, Carlos. Prognostic Significance of Circulating Tumor Cell Count in Patients With Metastatic Hormone-sensitive Prostate Cancer. UROLOGY 2012. 80: 1328-1332. FI: 2.424(Q2). PMID: 23063057. DOI: 10.1016/j.urology.2012.09.001.
Zapatero, Almudena, Martin De Vidales, Carmen, Arellano, Ramon, Ibanez, Yamile, Bocardo, Gloria, Perez, Mar, Rabadan, Mariano, Garcia Vicente, Feliciano, Cruz Conde, Jose A., Olivier, Carlos. Long-term Results of Two Prospective Bladder-sparing Trimodality Approaches for Invasive Bladder Cancer: Neoadjuvant Chemotherapy and Concurrent Radio-chemotherapy. UROLOGY 2012. 80: 1056-1062. FI: 2.424(Q2). PMID: 22999456. DOI: 10.1016/j.urology.2012.07.045.
Galante Romo, I, San Jose Manso, L. A., Casado Varela, J., Lopez Farre, A., Blazquez Izquierdo, J., Hernando Arteche, A., Sanz Ortega, J., Carballido Rodriguez, J., Gomez, Olivier Gomez, C. Transitional cell bladder cancer proteomic mapping and risk of progression. EUR UROL SUPPL 2012. 11(1): E897-U887. FI: 2.162(Q2).
Olivier Gómez C, Carballido Rodríguez J. Circulating tumor cells: isolation, quantification, and relevance of their translation into clinical practice. Actas Urol Esp 2010. 34:3-5. FI: 0.455(Q4). PMID: 20223125.