Advanced therapies in haematological disease

The Terapias Avanzadas en Oncohematología (Advanced Therapies in Oncohaematology) group from the Instituto de Investigación Sanitaria at the Hospital de La Princesa has a mission to promote clinical, epidemiological and translational research in haematological malignancies.

The group's scope is broad, reflecting the heterogeneous nature of each of its members' interests, ranging from genetic studies to commitment to new drug development.

The group has a differential interest in:

  • Epidemiological studies in chronic myeloid leukaemia.
  • Study of the efficacy and safety of new drugs in haematological malignancies.
  • Immunological and genetic studies in haematological malignancies.
  • Analysis of conditioning regimes in bone marrow transplantation (BMT).
  • Analysis of infectious complications in BMT.

Over the past five years, our clinical research has focused on two fields. The first, within the European Leukaemia Network EUTOS, in epidemiological studies and recommendations for good clinical practice. Secondly, within the Spanish CML group (GELMC), to promote clinical research in this group. A multi-centre clinical trial is currently underway and another is awaiting approval. We have built a mobile app for IOS, Windows and Android for information exchange between GELMC members.

On a local level, our goal is to establish common projects that could cover all haematological malignancies treated in our group. The plan is thus to establish studies on quality of life, comorbidities and pharmacology.

Team members
 

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Group leader:

Juan Luis Steegmann Olmedillas

Hospital Universitario La Princesa

  Other team members.Hospital Universitario La Princesa:

  • Adrián Alegre Amor
  • Eva María Arranz Muñoz
  • María Reyes Arranz Sáez
  • María Jimena Cannata Ortiz
  • Ángela Figuera Álvarez
  • Ana María García-Noblejas Moya
  • Valle Gómez García de Soria
  • Jimena Jiménez Braña
  • Javier Loscertales Pueyo
  • María Ángeles Sanz de Benito

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Jabbour E, Kantarjian HM, Saglio G, Steegmann JL, Shah NP, Boqué C, Chuah C, Pavlovsky C, Mayer J, Cortes J, Baccarani M, Kim DW, Bradley-Garelik MB, Mohamed H, Wildgust M, Hochhaus A. Early response with dasatinib or imatinib in chronic myeloid leukemia: 3-year follow-up from a randomized phase 3 trial (DASISION). Blood 2014. 123: 494-500. FI: 10.452(Q1). PMID: 24311723. DOI: 10.1182/blood-2013-06-511592.

Baccarani M, Deininger MW, Rosti G, Hochhaus A, Soverini S, Apperley JF, Cervantes F, Clark RE, Cortes JE, Guilhot F, Hjorth-Hansen H, Hughes TP, Kantarjian HM, Kim DW, Larson RA, Lipton JH, Mahon FX, Martinelli G, Mayer J, Müller MC, Niederwieser D, Pane F, Radich JP, Rousselot P, Saglio G, Saußele S, Schiffer C, Silver R, Simonsson B, Steegmann JL, Goldman JM, Hehlmann R. European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013. Blood 2013. 122: 872-884. FI: 9.775(Q1). PMID: 23803709. DOI: 10.1182/blood-2013-05-501569.

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