New therapies in infectious pathology

Community-acquired pneumonia (CAP) is an infectious disease with high prevalence and a high morbidity and mortality rate. Our group has been working on several lines in collaboration with various groups. Fundamentally we work in: A) Clinical indicators related to the safe management of patients with CAP. We participate as collaborators in several projects funded by the Sociedad Española de Neumología y Cirugía Torácica (Spanish Society of Pneumology and Thoracic Surgery). B) Our group maintains an open line of collaboration with several groups, mainly with the Department of Immunology at Hospital Dr. Negrín (Gran Canaria, Spain).

We collaborate on several topics, mainly mannose-binding lectin and surfactant protein, related to different aspects of host response in pneumonia. Financial support for this research has been possible through projects funded by FIS or scientific associations, in which we have participated as collaborating researchers. These two lines are active.

Our current research project addresses the incidence of cardiovascular events following CAP hospitalisation in adults, and their association with different markers of inflammation. As part of this project, we are aiming to quantify the incidence of cardiovascular disease in adult patients in the year following hospital admission due to CAP, and establish a possible relationship with mortality. In addition, we will attempt to describe the distribution of a broad spectrum of immune response mediators at hospital admission and discharge. This will allow us to characterise an inflammatory profile for these patients and determine a possible relationship with cardiovascular disease incidence.

Preliminary results are very promising: we have found a link between long-term mortality and the occurrence of cardiovascular episodes, as well as being able to select some biomarkers to improve the prediction of admission rates. We need more monitoring time to confirm the relationship between biomarkers and the development of cardiovascular episodes.

MicroRNAs (miRNAs) are a family of small, endogenous, non-coding RNAs that modulate physiological and pathological processes by post-transcriptional inhibition of gene expression. Recent studies have begun to reveal that altered expression profiles of miRNAs may be associated with the development of various lung diseases, from inflammatory diseases to lung cancer. Likewise, miRNAs are important for both adaptive and innate immunity, with regulatory effects on cell differentiation and immune function.

Recently the expression of different miRNAs in patients with cardiovascular episodes has also been published. We intend to explore the role of different miRNAs in the development of heart failure in patients with CAP and the regulation of inflammatory response in these patients.

Team members

area3_Linea7_G51_Dr-Aspa

Group leader:

Javier Aspa Marco

Hospital Universitario La Princesa

  Other team members.Hospital Universitario La Princesa:

  • Guillermo Fernández Jiménez
  • José María Galván Román
  • Jorge Gómez Zamora
  • Ángel Lancho Sánchez
  • Sergio Luquero Bueno
  • María del Mar Ortega Gómez
  • Olga Rajas Naranjo
  • Lorena Vega Piris

Aspa Marco, Javier. Incidencia de episodios cardiovasculares tras un ingreso hospitalario por neumonía adquirida. 089/2013. SEPAR. 2014-2015.

Ortega Gómez, María del Mar. Plataforma Nacional de Biobancos. PT13/0010/0058. ISCIII. 2014-2017.

Aspa Marco, Francisco Javier. La expresión de miRNAs circulantes libres y exosomales como predictores de la aparición de recurrencia y/o metástasis en pacientes intervenidos por cáncer de pulmón no microcítico. 98|2016. Sociedad Española de Neumología y Cirugía Torácica (SEPAR). 2017-2018.

Aspa Marco, Francisco Javier. Incidencia de episodios cardiovasculares tras un ingreso hospitalario por neumonía adquirida en la comunidad en pacientes adultos y su asociación con diferentes marcadores de inflamación. PI12/01142. ISCIII. 2013-2015.

Rajas Naranjo, Olga. Determinación del papel de los proteoglicanos en la interacción entre microorganismos y el tejido respiratorio. 125/2012. SEPAR. 2013-2015.

Aspa Marco, Francisco Javier. Identificación de microRNA implicados en la respuesta inflamatoria, aparición de eventos cardiovasculares y mortalidad en pacientes con neumonía adquirida en la comunidad. PI15/01311. ISCIII. 2016-2018.

Ortega Gómez, María del Mar. Plataforma de Biobancos. PT17/0015/0050. ISCIII. 2018-2020.

This grant is funded by the 2013-2016 Spanish Science, Technology and Innovation Research Plan and the ISCIII – Subdirectorate General for Evaluation and Promotion of Research – and co-financed by the European Regional Development Fund, Operational Programme Smart Growth 2014-2020 according to Regulation (EU) no. 1303/2013.

Rajas O, Ortega-Gómez M, Galván Román JM, Curbelo J, Fernández Jiménez G, Vega Piris L, Rodríguez Salvanes F, Arnalich B, Luquero Bueno S, Díaz López A, de la Fuente H, Suárez C, Ancochea J, Aspa J. The incidence of cardiovascular events after hospitalization due to CAP and their association with different inflammatory markers. BMC Pulm Med 2014. 14: 197-0. FI: 2.404(Q3). PMID: 25495677. DOI: 10.1186/1471-2466-14-197.

Bello S, Menéndez R, Torres A, Reyes S, Zalacain R, Capelastegui A, Aspa J, Borderías L, Martin-Villasclaras JJ, Alfageme I, Rodríguez de Castro F, Rello J, Molinos L, Ruiz-Manzano J. Tobacco Smoking Increases the Risk for Death From Pneumococcal Pneumonia. Chest 2014. 146: 1029-1037. FI: 7.483(Q1). PMID: 24811098. DOI: 10.1378/chest.13-2853.

García-Laorden MI, Rodríguez de Castro F, Solé-Violán J, Payeras A, Briones ML, Borderías L, Aspa J, Blanquer J, Rajas O, Marcos-Ramos JA, Herrera-Ramos E, García-Bello MA, Noda J, Ferrer JM, Rello J, Rodríguez-Gallego C. The role of mannose-binding lectin in pneumococcal infection. Eur Respir J 2013. 41: 131-139. FI: 7.125(Q1). PMID: 22523362. DOI: 10.1183/09031936.00174111.

Menendez, R., Torres, A., Reyes, S., Zalacain, R., Capelastegui, A., Aspa, J., Borderias, L., Martin-Villasclaras, J. J., Bello, S., Alfageme, I., de Castro, F. R., Rello, J., Molinos, L., Ruiz-Manzano, J.. Initial management of pneumonia and sepsis: factors associated with improved outcome. Eur Respir J 2012. 39: 156-162. FI: 6.355(Q1). PMID: 21828033. DOI: 10.1183/09031936.00188710.

Sole-Violan, Jordi, Isabel Garcia-Laorden, M., Alberto Marcos-Ramos, Jose, Rodriguez de Castro, Felipe, Rajas, Olga, Borderias, Luis, Luisa Briones, M., Herrera-Ramos, Estefania, Blanquer, Jose, Aspa, Javier, Florido, Yanira, Angel Garcia-Bello, Miguel, Maria Ferrer-Agueero, Jose, Sologuren, Ithaisa, Rodriguez-Gallego, Carlos. The Fc gamma receptor IIA-H/H131 genotype is associated with bacteremia in pneumococcal community-acquired pneumonia. Crit. Care Med. 2011. 39: 1388-1393. FI: 6.330(Q1). PMID: 21317643. DOI: 10.1097/CCM.0b013e31820eda74.