Diagnostic and therapeutic advances in affective disorders

The group is made up of professionals from different disciplines (psychiatry, psychology, neurology, biotechnology and social sciences) who work on various research projects funded through competitive public applications.

In recent years, the group has focused its lines of research on mental disorders, mainly on epidemiological, neurobiological, clinical and therapeutic aspects. Other areas of research include suicidal behaviour, well-being and population ageing within the theoretical framework of the International Classification of Functioning, Disability and Health (ICF).

Among the current lines of research, the following stand out:

1) Classification of mental disorders

Evaluation of the efficacy of different therapeutic strategies in patients with major depressive disorder and bipolar disorders.

Identification of inflammatory biomarkers in patients with major depressive disorder.

Needs assessment to increase participation and job performance of people with chronic illnesses (including depression).

3) Psychosis

Analysis of the role of environmental and biological factors and their interaction in the appearance of psychotic disorders, as well as their evolution over time.

Study of the molecular basis of metabolic changes associated with treatment with antipsychotics in patients with psychosis.

4) Epidemiology of mental illness

Identification of healthy ageing patterns, their determinants and critical points at which changes in trajectory occur, as well as proposal of public health interventions to optimise the ageing process.

5) Suicide

Study of the prevalence, evolutions and determinants for mental illness and suicide.

6) Welfare

Evaluation of the general state of health, functioning and well-being and their relationships with mortality and other socio-sanitary indicators.

Definition, epidemiology and factors associated with psychological well-being in the elderly.

Monitoring of repeated evaluations of the affective experience and its context in the flow of daily life.

7) Prevention and training

Prevention of mental disorders and suicide by training professionals not specialised in mental health.

Definition of improvement strategies for mental health care in developing countries.

Team members

Group leader:

José Luis Ayuso Mateos

Hospital Universitario La Princesa

  Other team members:

  • Montserrat Alcañiz Rodríguez. Hospital Universitario La Princesa.
  • María Cabello Salmerón. Universidad Autónoma de Madrid.
  • Chiara Castelletti. Universidad Autónoma de Madrid.
  • Eduardo Delgado Parada. Hospital Universitario de La Princesa.
  • Blanca Dolz del Castellar Blanco. Universidad Autónoma de Madrid.
  • María Elena Ezquiaga Terrazas. Hospital Universitario La Princesa.
  • Ana Izquierdo Zarzo. Hospital Universitario La Princesa.
  • Elvira Lara Pérez. Universidad Autónoma de Madrid.
  • Itziar Leal Leturia. Atención Primaria.
  • María Pilar López García. Hospital Universitario La Princesa.
  • Herminio Martínez Cano. Hospital Universitario La Princesa.
  • Marta Miret García. Universidad Autónoma de Madrid.
  • Daniel Vicente Morillo Cuadrado. Universidad Autónoma de Madrid.
  • Ana Ortiz-Tallo Moya. Universidad Autónoma de Madrid.
  • Kerry Rodríguez Mcgreevy. Universidad Autónoma de Madrid.
  • Yolanda Sánchez Carro. Universidad Autónoma de Madrid.
  • Iosune Torio Palmero. Hospital Universitario La Princesa.
  • Belen Unzeta Conde. Hospital Universitario Santa Cristina.
  • Alba Vieira Campos. Universidad Autónoma de Madrid.

Ayuso Mateos, José Luis. Trayectoria de salud mental, salud física y funcionamiento: tercera evaluación de una cohorte poblacional adulta. PI16/00218. ISCIII. 2017-2019.

Evaluación para conocer las trayectorias de salud y bienestar en la población española que envejece.

This grant is funded by the 2013-2016 Spanish Science, Technology and Innovation Research Plan and the ISCIII – Subdirectorate General for Evaluation and Promotion of Research – and co-financed by the European Regional Development Fund, Operational Programme Smart Growth 2014-2020 according to Regulation (EU) no. 1303/2013.


Ayuso Mateos, José Luis. Depresión, bienestar subjetivo, salud y mortalidad: un estudio longitudinal en población general. PI13/00059. ISCIII. 2014-2016.

This grant is funded by the State R&D&I Plan and the ISCIII-Subdirección General de Evaluación y Fomento de la Investigación, co-funded by FEDER (the Spanish Federation for Rare Diseases), Operational Programme for the Knowledge-Based Economy (2007-2013), in accordance with Council Regulation (EC) no. 1083/2006 of 11 July 2006 laying down general provisions on the European Regional Development Fund, the European Social Fund and the Cohesion Fund.

Ayuso Mateos, José Luis. MARATONE: Mental health training through research network in Europe. 31795. European Commission. 2013-2017.

Ayuso Mateos, José Luis. EMERALD:Emerging mental health systems in low- and middle-income countries. 305968. European Commission. 2012-2017.

Ayuso Mateos, José Luis. AGES: Ambiente y genes en esquizofrenia-grupos de investigación de la Comunidad de Madrid. S2010/BMD-2422. CAM. 2012-2015.

Ayuso Mateos, José Luis. PATHWAYS:Paticipation To Healthy Workplaces And inclusive Strategies in the Work Sector. 663474. European Commission. 2015-2017.

Ayuso Mateos, José Luis. ATHLOS:Ageing Trajectories of Health: Longitudinal Opportunities and Synergies. 635316. European Commission. 2015-2020.

López García, Pilar. TREATMENT: Training European Network: Metabolic Dysfunctions associated with Pharmacological Treatment of Schizophrenia. 674921. European Commission. 2016-2020.

Ayuso Mateos, Jose Luis. PRISM: Psychiatric Ratings using Intermediate Stratified Markers: providing quantitative biological measures to facilitate the discovery and development of new treatments for social and cognitive deficits in AD, SZ, and MD. 115916. European Commission. 2016-2019.

Ayuso Mateos, Jose Luis. Validez y utilidad clínica de una nueva taxonomía de trastornos mentales (CIE-11, OMS). World Health Organization. 2016-2018.

López García, Pilar. Estudio de marcadores periféricos de estrés oxidativo e inflamación en el Trastorno Depresivo Mayor. PI15/00204. ISCIII. 2016-2018.

This grant is co-funded by FEDER (Spanish Federation for Rare Diseases), Operational Programme for Intelligent Growth 2014-2020, in accordance with Regulation (EU) no. 1303 of the European Parliament and of the Council of 17 December 2013 laying down common rules for FEDER, the ESF and the Cohesion Fund, the EAFRD and the European Maritime and Fisheries Fund, and laying down general provisions for the European Regional Development Fund, the European Social Fund, the Cohesion Fund and the European Maritime and Fisheries Fund, and repealing Council Regulation (EC) no. 1083/2006; and in accordance with Regulation (EU) no. 1301/2013 of the European Parliament and of the Council of 17 December 2013 on the European Regional Development Fund.


Bonnin CM, Torrent C, Arango C, Amann BL, Solé B, González-Pinto A, Crespo JM, Tabarés-Seisdedos R, Reinares M, Ayuso-Mateos JL, García-Portilla MP, Ibañez Á, Salamero M, Vieta E, Martinez-Aran A, CIBERSAM Functional Remediation Group. Functional remediation in bipolar disorder: 1-year follow-up of; neurocognitive and functional outcome. Br. J. Psychiatry. 2016. 208:87-93. FI: 6.347(Q1). PMID: 26541692, DOI: 10.1192/bjp.bp.114.162123.

Ayuso-Mateos JL, Barros PP, Gusmão R. Financial crisis, austerity, and health in Europe. LANCET. 2013. 382:391-392. FI: 39.207(Q1). PMID: 23911369, DOI: 10.1016/S0140-6736(13)61663-3.

Arana A, Wentworth CE, Ayuso-Mateos JL, Arellano FM. Suicide-related events in patients treated with antiepileptic drugs.. N Engl J Med. 2010. 363:542-551. FI: 53.486(Q1). PMID: 20818889, DOI: 10.1056/NEJMoa0909801.

Moreno C, Nuevo R, Chatterji S, Verdes E, Arango C, Ayuso-Mateos JL. Psychotic symptoms are associated with physical health problems; independently of a mental disorder diagnosis: results from the WHO World; Health Survey. World Psychiatry. 2013. 12:251-257. FI: 12.846(Q1). PMID: 24096791, DOI: 10.1002/wps.20070.

Félix Caballero F, Soulis G, Engchuan W, Sánchez-Niubó A, Arndt H, Ayuso-Mateos JL, Haro JM, Chatterji S, Panagiotakos DB. Advanced analytical methodologies for measuring healthy ageing and its; determinants, using factor analysis and machine learning techniques: the; ATHLOS project. Sci Rep. 2017. 7:43955-43955. FI: 4.26(Q1). PMID: 28281663, DOI: 10.1038/srep43955.